Suitably designed units having the right mutual interaction will - under the right circumstances - assemble into a predetermined structure: on molecular scale this process leads to e.g. crystals or proteins. Here we want to exploit this process for units in the size range from a few tens of nanometres to hundreds of micrometres to assemble complex three-dimensional functional structures. Anisotropy in the particle properties is a major theme in the program. The applications of the self-assembly processes that we shall develop are (1) in packaging, where nano- and microunits such as circuits of sensing elements are spontaneously assembled to other systems, (2) in colloidal crystals having new (e.g. optical) properties and (3) in three-dimensional complex structures for sensing and three-dimensional electronics. The latter application is of strategic character because self-assembly seems to be the only route to realize three-dimensional systems from units of a size below a few 10’s of micrometers; this might provide a way to circumvent the end of Moore’s law, the rode map of electronics. The consortium in this program combines groups and companies based in supramolecular chemistry, polymer science, colloidal crystals, and microtechnology. We expect a strong cross-fertilization from the collaboration in such a multidisciplinary program. The input of industry is of major importance, and we wish to build the program on demand driven questions from industry. We target a total industrial contribution of 40% into the program, and foresee extensive visits of postdocs and PhD students in the laboratories of the industrial partners.

Initiatiefnemer(s)

Leon Abelmann, Miko Elwenspoek, Jurriaan Huskens, Julius Vancso, Willem Vos (UT) Klaas Besselink, Jan van Esch, Paddy French, Eduardo Mendez, Lina Sarro, Ernst Südholter (TUD) Martien Cohen Stuart, Mieke Kleijn (WUR) Alfons van Blaaderen, Willem Kegel, Daniel Vanmaekelbergh (UU) Ad Lagendijk (UvA) Marko Blom (Micronit) Rob van der Werf (ASML) George Robillard (BioMade) Joost Lotters (Bronkhorst) Leon Bremer (DSM) Andreas Dietzel, Erwin Meinders (Holst) Evangelos Eleftheriou (IBM) Henk Leeuwis (Lionix) John Schmitz (NXP) Johan Klootwijk (Philips) Robert Zwijze (Sensata) Daan Bijl (SmartTip) Arjen Broersma, Egbert-Jan Sol (TNO)

Openbare bijeenkomst

• 10 Juni, 11:30
• Micronit
• Colloseum 15
• Enschede

Contactpersoon/ trekker van het thema

• Miko Elwenspoek email
• PoBox 217
• 7500 AE Enschede
• +31 53 489 27 51

Percutaneous interventions are nonsurgical minimal invasive procedures using long flexible instruments like needles and catheters to diagnose and to treat diseased tissue. The major benefit of percutaneous interventions is in the introducing of the instruments through very small holes in the skin which heal very quickly compared to a surgical cut down. However, the lack of functionality at the tip of the existing instruments is severely limiting access to and treatment of many areas in the body. The objective of the iMIT program is the development of a new generation of percutaneous devices with highly advanced functionality at the tip for guiding and steering the instrument, and targeted treatment. A key aspect of this new functionality is the ability to characterize and to control the interaction of the instrument with the tissue. The core elements of the approach will be the use of optical, chemical, ultrasound, and mechanical principles and combinations thereof to come to the required novel sensing and actuation capabilities. The broad applicability of the new enabling techniques can be demonstrated within the program with the development of various needles and catheters for currently untreatable oncological and cardiovascular diseases, but also for reducing the invasiveness of other common procedures like biopsy taking and local drug delivery. The increased specificity of the procedures will make polyclinical treatment of many more diseases possible, which is especially of importance for the growing population of elderly patients.

Initiatiefnemer(s)

Prof. Jenny Dankelman (Technische Universiteit Delft), Prof. Ton van der Steen (ErasmusMC, Rotterdam), Prof. Dick Sterenborg (ErasmusMC, Rotterdam), Prof. Johan van Leeuwen (Universiteit Wageningen), Dr. Sarthak Misra (Universiteit Twente), Prof. Markus Hollmann (Academisch Medisch Centrum, Amsterdam), Prof. Wilco Peul (Leiden University Medical Center)

Openbare bijeenkomst

• 4 juli 2011, 14.00-17.00 uur
• STW
• Van Vollenhovenlaan 661
• 3527 JP Utrecht

Contactpersoon/ trekker van het thema

• Prof. dr. Jenny Dankelman email
• Afd. Biomechanical Engineering, TUDelft, Mekelweg 2
• 2628 CD Delft
• 015-278 5565

Single-photon technology is one of the most dynamic fields in contemporary physics and electronics research. The emergence of monolithic semiconductor technologies for the generation, detection, and transport of single photons is opening the way to e.g. better diagnostic imaging, more secure communications, and faster computing. Photomultiplier tubes, based on the photoelectric effect and electron multiplication, have existed since 1934; but it is only since the 1980s that single-photon avalanche diodes (SPADs) based on planar silicon processes have become available and only since 2003 that SPADs can be implemented in standard CMOS processes. With CMOS sensors, a new, still untapped potential for massively parallel single-photon detection and generation is emerging, with disruptive consequences in time-resolved imaging techniques such as time-of-flight (TOF) vision, fluorescence lifetime imaging microscopy (FLIM), positron emission tomography (PET), and molecular time-correlation spectroscopy (FCS). The outreach of single-photon technology is even growing beyond imaging, with great potential in ultra-secure encryption, quantum key distribution, high-speed data transmission, etc. Nevertheless, essential limitations of current single-photon technology, such as a relatively low level of integration, limited sensitivity, and high complexity, still prohibits its use in a broad range of applications. A consortium of Dutch scientists will work in close collaboration with key industrial partners to achieve crucial breakthroughs in single-photon technology. It is our goal to build megapixel single-photon sensors with (a) high sensitivity in a wide range of wavelengths and (b) sub-picosecond timing resolution, © to develop ultra-fast, real-time quantum signal processing methods, (d) to implement simultaneous space-time-polarization-energy (6D) imaging, and (e) to realize integrated single-photon generation and transport. The novel methods and technologies developed within the scope of this program will be tested and demonstrated in technically demanding applications of high societal relevance, including time-of-flight positron emission tomography (TOF-PET), quantum encryption, and fast, ultra-secure short- and long-distance data transmission.

Initiatiefnemer(s)

Edoardo Charbon (Technische Universiteit Delft), Dennis Schaart (Technische Universiteit Delft), Bram Nauta (Universiteit Twente), Jurriaan Schmitz (Universiteit Twente), Eugenio Cantatore (Technische Universiteit Eindhoven), Hans Gerritsen (Universiteit Utrecht), Marcel Pelgrom (NXP Semiconductors), Hans Hofstraat (Philips).

Openbare bijeenkomst

• Friday, June 24, 2011, 11:00 AM
• Faculty of EEMCS, Delft University of Technology
• Mekelweg 4
• Delft

Contactpersoon/ trekker van het thema

• Prof. dr. Edoardo Charbon email
• Mekelweg 4
• 2628 CD Delft
• +31 (0)15 27 83667

Graphene is a new and promising material. Less than ten years ago Geim and Novoselov produced the first flakes of graphene. Today, May 2011, it is clear that graphene will be introduced in displays soon by Samsung. A technology that delivers material of sufficient quality for this particular application is just around the corner. It is however totally unclear how far the applications of graphene will reach; think opto-electronic, high frequency, flexible. To expedite the introduction of graphene we propose a concurrent development of a graphene CVD deposition technology and application of the fabricated material in actual devices. Now is the time for such a program. The originally opposed technologies of silicon evaporation from a SiC substrate and CVD deposition on a metallic catalyst have converged, making CVD the probable technology. The kinetics of the CVD graphene growth and the materials science of the resulting graphene are however very far from understood and still at the level of (contradictory) recipes. The Netherlands is the place for such a program. Innovative companies like Philips, NXP, ASMI and Hauzer are expected to play an important role in application and fabrication of graphene.

Initiatiefnemer(s)

Prof.dr. J. Aarts Universiteit Leiden Prof.dr.ir. R. Dekker Philips Prof.dr. G.C.A.M.Janssen TU Delft Dr. I.J. Raaijmakers ASMI Prof.dr. J. Schmitz Universiteit Twente Ir. R. Tietema Hauzer Techno Coating Dr. A. Weisz Stratom Dr. R. Woltjer NXP

Openbare bijeenkomst

• in verband met toegang tot NXP uiterlijk 24-06-2011 aanmelden bij g.c.a.m.janssen@tudelft.nl

• 28 juni 2011, 14h00 – 16h00
• NXP, HTC4 1 413-415, melden, ophalen badge bij receptie HTC 37
• High Tech Campus 4
• Eindhoven

Contactpersoon/ trekker van het thema

• Prof.dr. G.C.A.M. Janssen email
• TU Delft, Mechanical, maritime, materials engineering (3mE), Mekelweg 2
• 2628 CD Delft
• 015-2781684

This program proposal serves as the continuation and extension of the successful Smart PEAS (Process Environment Actuators and Sensors) project within the Green and Smart Process Technologies program of the STW. The goal is to build an in-liquid wireless sensor network to measure and possibly control various types of liquid-based industrial processes. The sensors are floating around in the liquid process and are continuously measuring important parameters of the process. The measurements as well as the locations where they are taken, are wirelessly collected in a centralized or decentralized manner, and can further be used to validate certain process characteristics or initiate certain control actions. This way the industrial process can be optimized, leading to improved product quality and less by-product formation. Within the Smart PEAS project a proof of concept has been developed and some initial test platforms have been built. However, there are still many open ends that need to be investigated, such as the choice between using electromagnetic waves or acoustic waves for communication and localization. Furthermore, extensions to other applications will be looked at, such as more general in-liquid tracking and tracing systems. This program is fully interdisciplinary with challenges in localization, communications, sensor design, analogue and digital electronics, antenna design, flow dynamics, process industry and so on.

Initiatiefnemer(s)

Geert Leus, Delft University of Technology

Openbare bijeenkomst

• June 22, 2011, 14:00
• Delft University of Technology - Fac. EWI
• Mekelweg 4, Bordewijkzaal (19.130)
• Delft

Contactpersoon/ trekker van het thema

• Geert Leus email
• Mekelweg 4
• 2628 CD Delft
• 015-2784327

Robust coastlines are crucial to protect low-lying, often highly urbanized regions around the world against flooding. Natural beaches and dunes are increasingly used to achieve a robust coastline. The creation of wider natural coastlines also provides key opportunities for nature development and recreation. The most common approach to create a wider coastline is to bring the coastline linearly forward by sand nourishment. As this approach is increasingly used in ever growing quantities globally, a better compliance with ecological and social requirements is required. This is the inspiration behind the Sand Engine pilot project (www.zandmotor.nl). It consists of a locally concentrated mega-nourishment for the Delfland coast that will gradually diffuse creating shoreline widening along the adjacent coasts. The project is realized in 2011 and will be subject to extensive monitoring in the period 2012-2016. The aim of this initiative is to mobilize multi-disciplinary research efforts to develop thorough understanding of the morphological and ecological behavior of the Sand Engine, including its effects on ground water and nearshore currents. Governance specialists are involved to assess its feasibility in coastal management practice. This knowledge will enable to assess the feasibility of the Sand Engine concept as an alternative to linear nourishment on a global scale. The research will be carried out in close concert between public authorities, private companies and research institutes.

Initiatiefnemer(s)

Marcel Stive, Huib de Vriend (Delft University of Technology), Gerben Ruessink (Utrecht Univeristy), Maurice Paulissen, Martin Baptist (Wageningen University), Gerard Janssen (University of Amsterdam), Kris Lulofs, Bas Borsje (University of Twente), Jasper Griffioen (Deltares), Stefan Aarninkhof (EcoShape)

Openbare bijeenkomst

• 28 juni 2011, 14h00-16h00
• Ecoshape, Building with Nature
• Burgemeester de Raadtsingel 69
• 3311 JG Dordrecht

Contactpersoon/ trekker van het thema

• Marcel Stive email
• Stevinweg 1
• 2628 CN Delft
• +31 15 2785487

The number of applications for wireless systems is increasing rapidly, both in broadcast and telecommunication systems and in newer application areas such as wireless sensor networks and body-area networks. The number of nodes as well as the datarates in such networks is also increasing very rapidly. This increasing number of devices and data rates together with the limited resources (power, frequency, spatially), is the driver for the development of a new generation of wireless systems. The ambition of the proposed program is to develop new techniques to optimally use the available resources – a route to sustainable wireless systems. We think that a cross-layer and multidisciplinary approach is the only route to address this. This will be done in the “Wireless turns Green”-program in which the following aspects will be addressed: co-existence of many radio systems, minimizing EM-radiation exposure, and new techniques for extreme complex wireless systems.

Initiatiefnemer(s)

Universiteit Twente: Bram Nauta, Gerard Smit, Geert Heijenk, Eric Klumperink, Kees Slump; TU/e: Peter Baltus, Jan Haagh, Piet Sommen, Frans Willems; TUD: Ignas Niemegeers, Geert Leus, Alex Yaravoy; NXP: Gerard Beenker; Devlab: Lex van Gijsel; ASTRON: Albert-Jan Boonstra; AT: Helmut Leonard; en anderen

Openbare bijeenkomst

• Maandag 27 juni, 13:30
• STW gebouw - zaal 2A
• Van Vollenhovenlaan 661
• Utrecht

Contactpersoon/ trekker van het thema

• Mark Bentum email
• Postbus 217
• 7500 AE Enschede
• +31534892108

Today most electronic systems are developed with static models of its physical environment. For advanced systems that work in a fast changing environment, such as medical imaging systems and high-end printers, a static model of the environment is not sufficient anymore. These systems require a closed loop control system, which means that the environment (the plant) is observed by sampling many sensors at high sampling rates, and via digital processing of the sensor readings actuators are driven to influence the environment. For example: in future wafer scanners the requirements for speed and accuracy are so high that their mechanics becomes non-rigid; non-ideal mechanics has to be compensated by a high speed closed loop control system. These closed loop design problems are found in many areas, including automotive, printing, energy infrastructures, healthcare and transportation. These systems can not be designed cost effectively with current design techniques. Above systems, which require a tight combination of, and coordination between, the system’s computational and physical elements are called cyber-physical systems (CPS) [1]. They have to be extremely reliable, satisfy real-time requirements, and have to be very cost efficient. This means that the physical and electronic (embedded HW and SW) parts can not be designed independently anymore. Trade-offs are needed between the quality of physical design (e.g. mechanics or optics), and complexity and performance of the embedded control. To achieve this, hybrid modeling, analysis and synthesis techniques, integrating continuous time models for the physical system and discrete event based models for the digital part, have to be researched, developed and applied. A hybrid model will be the input for the design space exploration, an exploration which goes far beyond the rational HW-SW boundary of the controlling embedded system. Use of above Cyber Physical design approach solves current road blocks in designing CPSs. Furthermore, it increases their adaptability, autonomy, efficiency, functionality, reliability, safety, and usability. It broadens the potential of these systems in several dimensions, including: intervention (e.g., collision avoidance); precision (e.g., robotic surgery and high precision wafer scanners); operation in dangerous or inaccessible environments (e.g., search and rescue, firefighting, and deep-sea exploration); efficiency (e.g., zero-net energy buildings, smart grids); and augmentation of human capabilities (e.g., healthcare monitoring). The proposed program focuses on: • Advanced applications of merging physics and computing; • Modeling and analysis of CPSs, including analog, digital hardware and software co-design; • Fast simulation of CPSs; • Design space exploration methods for dependable CPSs.

Initiatiefnemer(s)

Gerard Smit (UT) Henk Corporaal (TU/e)

Openbare bijeenkomst

• 30 juni op TU/e (en evt. extra bijeenkomst 1 juli op UTwente), 14.00 uur
• TU/e
• Den Dolech 2
• Eindhoven

Contactpersoon/ trekker van het thema

• Gerard Smit email
• University of Twente PO Box 217
• 7500 AE Enschede
• +31 53 4893734

With growing population, increasing urbanization and industrial activity, water demands are rising and high-quality water resources are becoming scarce, both nationally and internationally. New solutions must be found to secure adequate water supply. In this program, a paradigm shift is introduced: water resources with a reduced quality will be used to produce water of sufficient quality (water fit-for-use) for application in agriculture and food and chemical industry. New purification technologies will be developed to remove only those impurities (particulate, chemical or microbial parameters) that need to be removed for making water fit for a specific use. Sensors will be developed to support smart purification.

Initiatiefnemer(s)

Prof. dr. Ir. Luuk Rietveld, Delft University of Technology Prof. dr. Ir. Huub Rijnaarts, Wageningen University and Research Center Prof. dr. Pim de Voogt – University of Amsterdam Prof. dr. Ir. Jan Peter van der Hoek – Waternet Prof. dr. Ir. Walter van der Meer - Vitens

Openbare bijeenkomst

• 27 juni 2011, 10:00 – 12:00 uur
• Wageningen Universiteit en Research Centrum, Gebouw 118, Kamer TT-1-0.02
• Bornse Weilanden 9, SVP melden bij receptie in Atrium / gebouw 118
• 6708 WG Wageningen

Contactpersoon/ trekker van het thema

• Prof. dr. ir. L.C. Rietveld email
• Stevinweg 1
• 2628 CN Delft
• +31152784732/+31624996764

Treatment of diseases in the human body, such as the therapy of cancer and cardiovascular diseases, are tuned to the individual patient. For therapy to be successful in-situ monitoring of drug delivery and uptake, a direct feedback of non-invasive and minimally invasive procedures and a rapid evaluation of therapeutic efficiency are essential. In this program we develop novel imaging concepts with the leading medical device industries in the Netherlands, Europe and US to be used during therapeutic procedures. In this concept we push established diagnostic and functional imaging into the unexplored field of therapeutic imaging to open up combined imaging techniques for processes down to the cellular level with the aid of specific nanoparticles. This program explores the physical interaction parameter space of sound, light and magnetism with these novel functionalized particles for therapeutic imaging, which includes the development and synthesis of new biomarkers, labeling and binding strategies against specific disease, and the fundamental understanding and subsequent processing of the received response. The final aim of this program is to evaluate the newly obtained therapeutic imaging technologies at the level of preclinical models of disease.

Initiatiefnemer(s)

Dr. Michel Versluis (Universiteit Twente), Prof. Nico de Jong (Erasmus MC Rotterdam), Prof. Klaas Nicolay (Technische Universiteit Eindhoven), Prof. Ton van Leeuwen (AMC Universiteit van Amsterdam)

Openbare bijeenkomst

• 4 juli 2011, 10:00-12:00
• Regardz Meeting Center Eenhoorn
• Koningin Wilhelminalaan 33
• 3818 HN Amersfoort

Contactpersoon/ trekker van het thema

• Dr. Michel Versluis email
• Universiteit Twente, Postbus 217
• 7500 AE Enschede
• +31 53 489 8077

Population imaging has the potential to see disease develop before your eyes. It provides unique databases, often including genetic data, that can be exploited for early detection and prediction of disease, supporting the trend from treatment to prevention. To exploit the richness of these data new ICT research is required, as the current standard of semi-supervised exploration is impossible to apply. This project will therefore focus on (1) Medical image processing technology to track backwards to identify the early signs of disease and beyond into the precursors for disease (2) Integrated imaging and genetic data analysis for early signs and cause-consequence analysis (3) Unknown pattern search correlated with later signs of disease by search engines in large heterogeneous databases.

Initiatiefnemer(s)

Prof. Dr. W. J. Niessen, Erasmus MC / TU Delft Prof. Dr. B.P.F.J. Lelieveldt, LUMC / TU Delft Prof. Dr. Ir. A.W.M. Smeulders, UvA Prof. Dr. Ir. M. Breeuwer, Philips Healthcare / TU Eindhoven Dr. B. Goedhart, Medis Medical Imaging BV Dr. T. van Mil, Immovator

Openbare bijeenkomst

• 30 juni 2011, 15:00
• Erasmus MC, kamer V-113
• Dr Molewaterplein 50/60
• Rotterdam

Contactpersoon/ trekker van het thema

• Prof. Dr. W. J. Niessen email
• Kamer EE 2151, Erasmus MC, Posbus 2040
• 3000 CA Rotterdam
• 010 704 4119

Recent years have shown a strong increase in interest in the use of complementary correlative techniques in microscopy. Combining results of optical microscopy and electron microscopy on the same specimen turns out to be particularly powerful. For instance, fluorescence microscopy is used to identify regions of interest in large fields of view after which the ultrastructure of the same area is studied by TEM. Unfortunately, the success rate of this approach is limited when separate instruments are used. Recently, fluorescence microscopy and EM were successfully integrated in one setup and results in both life sciences and material sciences exemplified the efficiency and power of this combination. This initiative is focused on the further development of integrating different imaging modalities and EM in one setup. Promising combinations of techniques that we envisage include: TEM and super resolution light microscopy, SEM and 3D confocal microscopy, SEM and Raman spectroscopy/microscopy, FIB/SEM and confocal microscopy. The latter combination would allow milling of the specimen and optical probing of its properties. Besides these hardware developments efforts are anticipated in the area of (fluorescent) probe development as well as experiments in life sciences and material sciences to validate the novel instrumentation. Initiatiefnemer(s): Hans Gerritsen - Universiteit Utrecht, Jacob Hoogenboom - TU Delft, Cees Otto - TU Twente, Frank de Jong - FEI, Ir. Loretta van Kollenburg HybriScan Technologies b.v., Sander den Hoedt Delmic b.v.

Initiatiefnemer(s)

Hans Gerritsen - Universiteit Utrecht, Jacob Hoogenboom - TU Delft, Cees Otto - TU Twente, Frank de Jong - FEI, Loretta van Kollenburg HybriScan Technologies b.v., Sander den Hoedt Delmic b.v.

Openbare bijeenkomst

• 29 June, 10.00-14.00
• Kruyt gebouw zaal O112
• Padualaan 8, Uithof
• Utrecht

Contactpersoon/ trekker van het thema

• Prof.dr. Hans Gerritsen email
• Universiteit Utrecht, Debye Institute, Science Faculty
• 3584 CC Utrecht
• +31 30 2532824

The potential use of micro- and nanospheres in regenerative medicine in general and regeneration of bone and cardiovascular tissue in particular has drawn increasing interest, either as a method for improved drug delivery or for improving the structural properties of synthetic grafts. During the past decade, the Netherlands has gained a strong position within this emerging research field. The goal of this program is to strengthen the Dutch position on research and development of micro- and nanospheres further by bringing together the important players in this field and unifying the as yet scattered research efforts. Four main topics will be studied in the program that are related to the application of micro- and nanospheres in bone and cardiovascular regeneration: i) improving the clinical efficacy of drug delivery either by stimulus-free or stimulus-sensitive release of biomolecules, ii) developing spheres that introduce porosity into and/or improve the mechanical properties of bulk scaffolds by acting as porogen or reinforcement phase, iii) developing spheres as compartmentalized microreactors for dedicated biochemical processes, and finally iv) developing injectable and/or moldable formulations based on spheres e.g. to be applied using minimally invasive surgery. Besides the participation of leading academic partners, strong industrial support for this program is guaranteed by the active involvement of several private partners (Innocore, Nanomi, Encapson, Future chemistry as SME’s and DSM as multinational) and the BMM (BioMedical Materials) program as the largest Dutch public-private partnership in biomedical materials.

Initiatiefnemer(s)

Prof. dr. Paul Quax (Leiden University Medical Center), Prof. dr. ir. Wim Hennink (Utrecht University), Dr. ir. Sander Leeuwenburgh (Radboud University Nijmegen Medical Center), Dr. Marc Hendriks (DSM), Dr. Rob Steendam (Innocore), Dr. ir. Gert Veldhuis (Nanomi), Dr. Dennis Vriezema (Encapson), Dr. Pieter Nieuwland (Future Chemistry), Dr. Emiel Staring (BMM)

Openbare bijeenkomst

• 1 July, 11.00-13.00
• Radboud University Nijmegen Medical Center
• Philips van Leydenlaan 25, Tandheelkunde Building, Room -1.22
• Nijmegen

Contactpersoon/ trekker van het thema

• Sander Leeuwenburgh email
• Philips van Leijdenlaan 25
• 6525 EX Nijmegen
• +31-(0)24-3667305